{"id":3745,"date":"2020-09-16T14:49:02","date_gmt":"2020-09-16T12:49:02","guid":{"rendered":"http:\/\/18.198.170.41\/?p=3745"},"modified":"2022-04-25T13:39:37","modified_gmt":"2022-04-25T11:39:37","slug":"is-a-compound-worth-its-weight-in-gold","status":"publish","type":"post","link":"https:\/\/blog.molport.com\/news\/is-a-compound-worth-its-weight-in-gold\/","title":{"rendered":"Is a Compound Worth Its Weight In Gold?"},"content":{"rendered":"

What\u2019s the\u00a0most expensive available, elemental material<\/a>\u00a0that you can buy? No, it\u2019s not gold: as of September 7, gold was trading at\u00a0$62.32 per gram<\/a>, but lutetium costs $100 per gram, and californium (which has to be made) costs $27M per gram.<\/p>\n

What about synthetic organic compounds? Surely, they can\u2019t cost so much, can they? Well actually \u2026. yes, they can. A quick search in MolPort\u2019s comprehensive 7M+\u00a0database<\/a>\u00a0of available screening compounds and building blocks shows that the most expensive compound on file sells for $3995 per milligram, 64,104 times more expensive than gold on a weight-for-weight basis!\u00a0Here it is:<\/a><\/p>\n

\"\"
3-hydroxy-11-methoxy-6,8,19-trioxapentacyclo[10.7.0.0\u00b2,\u2079.0\u00b3,\u2077.0\u00b9\u00b3,\u00b9\u2077]nonadeca-1,9,11,13(17)-tetraene-16,18-dione Molecular formula: C17H14O7; Molecular weight: 330.292 SMILES: COc1cc2OC3OCCC3(O)c2c2oc(=O)c3C(=O)CCc3c12 InChI key: OQLKWHFMUPJCJY-UHFFFAOYSA-N<\/figcaption><\/figure>\n
\n
Could this be a promising lead? Based on its structural properties, it certainly passes the\u00a0Pfizer Rule of Five<\/a>\u00a0for drug likeness, and a quick search for its InChIKey in PubChem and ChemSpider would show whether it had appeared in any publications. So perhaps it is worth including it in a screening library.<\/div>\n
<\/div>\n
But can a molecule like this really be worth so much? Maybe. Suppose that it is a key structure needed to complete a crucial structure-activity relationship study that will determine whether a new drug project will continue or be stopped. If the compound is not readily available, the project could be held up while chemists work out how to make it.<\/div>\n
<\/div>\n
Suppose they work out a synthesis scheme with five steps, each taking a week to complete. That already puts the project back by over a month. And if a single chemist works on the synthesis, even at 50% of their time, that\u2019s 100 hours of work or a cost of $9375 (based on $180K per annum for a fully loaded FTE).<\/div>\n
<\/div>\n
So maybe that $3995 doesn\u2019t look so bad after all: the project can move ahead quickly, the chemists are freed up to work on other more worthwhile compounds, and the company has saved some $$.<\/div>\n
<\/div>\n<\/div>\n
See what else is on Top 20 list:<\/strong><\/div>\n
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MolPort-006-394-415<\/a><\/div>\n
MolPort-046-702-455<\/a><\/div>\n
MolPort-046-196-739<\/a><\/div>\n
MolPort-046-788-463<\/a><\/div>\n
MolPort-046-418-188<\/a><\/div>\n
MolPort-046-418-788<\/a><\/div>\n
MolPort-035-817-546<\/a><\/div>\n
MolPort-035-817-547<\/a><\/div>\n
MolPort-046-836-664<\/a><\/div>\n
MolPort-046-417-985<\/a><\/div>\n
MolPort-004-964-414<\/a><\/div>\n
MolPort-046-702-048<\/a><\/div>\n
MolPort-046-702-260<\/a><\/div>\n
MolPort-046-702-048<\/a><\/div>\n
MolPort-046-702-702<\/a><\/div>\n
MolPort-039-139-477<\/a><\/div>\n
MolPort-046-418-456<\/a><\/div>\n
MolPort-046-773-767<\/a><\/div>\n
MolPort-046-773-769<\/a><\/div>\n
MolPort-046-773-758<\/a><\/div>\n<\/div>\n
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<\/i> Subscribe to our newsletter and stay updated<\/strong> <\/span><\/a><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

What\u2019s the\u00a0most expensive available, elemental material\u00a0that you can buy? No, it\u2019s not gold: as of September 7, gold was trading at\u00a0$62.32 per gram, but lutetium costs $100 per gram, and californium (which has to be made) costs $27M per gram. What about synthetic organic compounds? Surely, they can\u2019t cost so much, can they? Well actually<\/p>\n","protected":false},"author":6,"featured_media":3966,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[70,71],"tags":[],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/blog.molport.com\/wp-json\/wp\/v2\/posts\/3745"}],"collection":[{"href":"https:\/\/blog.molport.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blog.molport.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blog.molport.com\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/blog.molport.com\/wp-json\/wp\/v2\/comments?post=3745"}],"version-history":[{"count":5,"href":"https:\/\/blog.molport.com\/wp-json\/wp\/v2\/posts\/3745\/revisions"}],"predecessor-version":[{"id":4003,"href":"https:\/\/blog.molport.com\/wp-json\/wp\/v2\/posts\/3745\/revisions\/4003"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/blog.molport.com\/wp-json\/wp\/v2\/media\/3966"}],"wp:attachment":[{"href":"https:\/\/blog.molport.com\/wp-json\/wp\/v2\/media?parent=3745"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blog.molport.com\/wp-json\/wp\/v2\/categories?post=3745"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blog.molport.com\/wp-json\/wp\/v2\/tags?post=3745"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}