{"id":4707,"date":"2025-05-06T14:02:01","date_gmt":"2025-05-06T12:02:01","guid":{"rendered":"https:\/\/blog.molport.com\/?p=4707"},"modified":"2025-09-02T08:28:01","modified_gmt":"2025-09-02T06:28:01","slug":"molport-chronicles-from-alchemy-to-pharma-2","status":"publish","type":"post","link":"https:\/\/blog.molport.com\/news\/molport-chronicles-from-alchemy-to-pharma-2\/","title":{"rendered":"Molport Chronicles- from Alchemy to Pharma No. 2"},"content":{"rendered":"<h2>Dose Makes The Poison<\/h2>\n<p><span data-contrast=\"auto\">Today I\u2019d like to tell you about a Swiss gentleman named <a href=\"https:\/\/en.wikipedia.org\/wiki\/Paracelsus\">Paracelsus<\/a>.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Often called the \u201cfather\u201d of modern toxicology and pharmacology, Paracelsus was the first to articulate a principle that still underpins toxicology today: \u201c<a href=\"https:\/\/en.wikipedia.org\/wiki\/The_dose_makes_the_poison\">The dose makes the poison<\/a>.\u201d He argued that no substance is inherently toxic; it all depends on how much of it you take. Even substances we consider harmful can be beneficial in tiny amounts. Paracelsus famously used small doses of arsenic to treat patients with syphilis. And it&#8217;s not just poisons. Take water, for example, essential for life, yet potentially dangerous. Drinking 6\u20137 liters in a short time can overwhelm the body\u2019s ability to regulate electrolytes and can be life-threatening.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">\u00a0Paracelsus\u2019s pioneering belief that substances could heal or harm depending on dosage laid the foundational principle for modern drug development, shaping how clinical trials are designed today, with precise dose-ranging studies, safety thresholds, and efficacy evaluations all rooted in the idea that the right dose makes the difference between a remedy and a poison.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-large wp-image-4710\" src=\"https:\/\/blog.molport.com\/wp-content\/uploads\/2025\/06\/Alchemy-to-Pharma-27April-1-1024x1024.png\" alt=\"Molport Chronicles- from Alchemy to Pharma | Paracelsus- dose makes the poison \" width=\"770\" height=\"770\" srcset=\"https:\/\/blog.molport.com\/wp-content\/uploads\/2025\/06\/Alchemy-to-Pharma-27April-1-1024x1024.png 1024w, https:\/\/blog.molport.com\/wp-content\/uploads\/2025\/06\/Alchemy-to-Pharma-27April-1-300x300.png 300w, https:\/\/blog.molport.com\/wp-content\/uploads\/2025\/06\/Alchemy-to-Pharma-27April-1-150x150.png 150w, https:\/\/blog.molport.com\/wp-content\/uploads\/2025\/06\/Alchemy-to-Pharma-27April-1-370x370.png 370w, https:\/\/blog.molport.com\/wp-content\/uploads\/2025\/06\/Alchemy-to-Pharma-27April-1.png 1200w\" sizes=\"(max-width: 770px) 100vw, 770px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dose Makes The Poison Today I\u2019d like to tell you about a Swiss gentleman named Paracelsus.\u00a0 Often called the \u201cfather\u201d of modern toxicology and pharmacology, Paracelsus was the first to articulate a principle that still underpins toxicology today: \u201cThe dose makes the poison.\u201d He argued that no substance is inherently toxic; it all depends on<\/p>\n","protected":false},"author":6,"featured_media":4708,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[70],"tags":[156,158,157],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/blog.molport.com\/wp-json\/wp\/v2\/posts\/4707"}],"collection":[{"href":"https:\/\/blog.molport.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blog.molport.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blog.molport.com\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/blog.molport.com\/wp-json\/wp\/v2\/comments?post=4707"}],"version-history":[{"count":5,"href":"https:\/\/blog.molport.com\/wp-json\/wp\/v2\/posts\/4707\/revisions"}],"predecessor-version":[{"id":4732,"href":"https:\/\/blog.molport.com\/wp-json\/wp\/v2\/posts\/4707\/revisions\/4732"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/blog.molport.com\/wp-json\/wp\/v2\/media\/4708"}],"wp:attachment":[{"href":"https:\/\/blog.molport.com\/wp-json\/wp\/v2\/media?parent=4707"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blog.molport.com\/wp-json\/wp\/v2\/categories?post=4707"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blog.molport.com\/wp-json\/wp\/v2\/tags?post=4707"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}