Natural and Natural-Like Compound Database

Natural products

A natural product is a chemical compound found in the nature. Such products are important for use in cosmetics, food and nutrition industries due to their properties and commercial image. Many active pharmaceutical compounds are natural products or derivatives of natural compounds. Typically, such compounds have better bioavailability than synthetic compounds.

In recent years there has been growing interest to test natural compounds in lead discovery. There are free and paid access databases of natural products. These databases extract information from scientific literature and other sources and they usually contain extended information about each compound. However, these databases lack information about commercial sources of samples of these compounds. Lead discovery scientists are often frustrated by low success rate of sourcing samples for screening.

S. O'Hagan and D.B. Kell at University of Manchester recently published an interesting comparison of MolPort and proprietary Natural Product database data, with the goal of creating available-to-purchase natural product diversity sets. Please, contact us if you are considering purchasing this or similar natural product set. We can provide unique offer at your request.

The MolPort natural products database

MolPort database of commercially available compounds aggregates catalogues of reliable chemical suppliers. Many suppliers offer natural products as well. We have collected information on over 10,000 unique natural and over 100,000 natural-like products from our suppliers and made it available via downloadable files. Some of natural compounds in our selection are not listed in commercial natural product databases.

The MolPort natural product files are available for download via our FTP service. You will find them in the 'Natural Products' folder in SDF and SMILES formats. Both formats contain the compound structure, the MolPort ID, an identifier for the highest potential class of natural compound, class description and a link to the dedicated molecule page.

You can request credentials for your free access to the MolPort FTP service by contacting our Customer Support or by filling and submitting the contact us form.

Natural product classification

Upon our request, suppliers classified their natural and natural-like products according to the following ranked classification rules:

Category Abbreviation Description
Naturally sourced NS the sample was isolated from a natural source
Genuine natural GN the compound occurs in nature, but the specific product may have been produced synthetically
Natural compound derivatives ND the compound is a derivative from GN
Natural-like NL mimetics or analogs

Our files contain information on the highest potential class available.

For example, if a supplier has no evidence of a product occurring in nature, they can classify it as 'natural-like' (NL); however, another supplier may provide a product based on the same molecule, which is sourced from plant extracts and can be classified as 'naturally sourced' (NS). In this case our file will contain the compound category 'naturally sourced' for this molecule.

Suppliers offering natural and natural-like compounds

The following suppliers have already provided their data for natural products classification:

# Supplier Name Number of Products
1. InterBioScreen Ltd. 66,798
2. AnalytiCon Discovery, GmbH 30,322
3. ChemDiv, Inc. 18,497
4. ChemFaces 5,149
5. BioBioPha 3,146
6. Life Chemicals Inc. 2,593
7. Cayman Europe 2,232
8. Otava, Ltd. 1,997
9. Specs 763
10. HTS Biochemie Innovationen 429
12. Alinda Chemical, Ltd. 200
13. BIONET/Key Organics Ltd. 183
14. EDASA Scientific 134
15. Ramidus AB 105

Note: the actual data on number of products available for sale may be less due to sold out products and other factors. Bear in mind the total number of molecules available in our files will be less, since one compound is often provided by multiple suppliers.

Q/A: Does MolPort have information about the source of natural products?

Some suppliers provide this information, whereas others do not, or at least not for free. Please contact us to discuss your request. Please take in account, that the same compounds from the same supplier can be sourced from various species, depending on the batch.

Q/A: Does MolPort work with extracts or fractions (mix of compounds)?

No. However, some of our suppliers do.

2018 MolPort, v2.56, release date 04-00-2018 10:00 (+0200). All rights reserved.
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